An experiment is described that is suitable for the early portion of the laboratory in a general chemistry course and integrates organic examples it is the two-step synthesis of aspirin starting from oil of wintergreen the mechanism for this synthesis provides examples of three major classes of. Paracetamol (acetaminophen) is sold under the names panadol® 1 in the uk, australia and new zealand and under the name tylenol® 2 in the usa paracetamol (acetaminophen) is an aromatic compound containing an oh (hydroxyl) functional group and a hn-co-r ( amide ) functional group. Aspirin synthesis and analysis revised: 12/13/14 cooled to freeze) in this experiment, you will measure the melting point of your synthesized. The williamson ether synthesis the williamson ether synthesis is an organic reaction, forming an ether from an alkyl acetaminophen 3 turn off the heat allow the mixture to cool down add 4 ml of water to the the experiment 7 extract the organic layer with 25 ml, of.
What a pain phenacetin synthesis from acetaminophen synthesize phenacetin from acetaminophen 1 synthesis a grind 2 tablets of tylenol (350 mg of acetaminophen per tablet or an equivalent amount) using a mortar and pestle repeat the experiment except this time use the microwave oven to heat your reaction mixture instead of doing a. Experiment 1 synthesis of acetaminophens esterification reaction: the synthesis and purification of 2- the purpose of the experiment is to 1 mixture of ethyl acetate and methylene chloride. Add 10 drops of aqueous 1% ferric chloride solution to a test tube containing a few crystals of the compound to be tested dissolved in 5 ml water and note the color do this test with 1phenol, 2 salicylic acid, and 3 your crude product. The experimental procedure used for this experiment was outlined in the chem 123l lab manual, experiment #1, synthesis of acetaminophen, pages 12-15 a slight change was made to the one material that was used.
Synthesis and purification of the analgesic agent, acetaminophen (paracetamol) introduction: acetaminophen is a non-steroidal anti-inflammatory/analgesic agent, it has also anti-pyretic properties. (04:141) experiment #4 1 synthesis of acetaminophen and analysis of some common analgesics background in this experiment, p-acetamidophenol (acetaminophen) will be prepared from p- aminophenol by reaction with acetic anhydride. Acetanilide is an odourless the preparation used to be a traditional experiment in introductory organic chemistry lab classes, and camphor synthesis acetanilide is used for the production of 4-acetamidobenzenesulfonyl chloride, a key intermediate for the manufacture of the sulfa drugs. Record the weight of the dry, recrystallized acetaminophen and the % recovery from recrystallization (eg if you obtain 075 g recrystallized product after starting with 10 g crude product you have 075/10 x 100 = 75% recovery record the percent theoretical yield of dry recrystallized product. 12 answer the analysis questions (below) for week 1 in your lab notebook sign and date the last page of your experiment ask the instructor to check and sign your lab notebook.
Synthesis of acetyl salicylic acid (aspirin) essay date experiment conducted: 05/02/2009 date report written: 08/02/2009 synthesis of acetyl salicylic acid (aspirin) abstract introduction: the following report contains information on how to produce aspirin. Chem 123l lab report synthesis of acetaminophen [type the author name] introduction: acetaminophen, first introduced in 1955, is an over-the-counter drug that relieves pain and 1 in this experiment crude acetaminophen was purified using the technique of recrystallization. Calculate the theoretical yield of your acetaminophen actual mass and moles of p-aminophenol used: 151g and 00137 mol actual mass of acetic anhydride: 2ml 108ml = 216g and 00211 mol limiting reagent: p-aminophenol theoretical yield of acetaminophen: 2071g and 00137 mol 2.
Yield for recrystallized phenacetin = 100% = 38 12% for this experiment, acetaminophen was the limiting reagent hence the crude product gave a yield of 76 06% while the recrystallized product gave a yield of 38 12. Acetaminophen is created by synthesising p-aminophenol with acetic anhydride this reaction occurs when the aminoalkane group of the p-aminophenol is acetylated by the acetic anhydride the end point is an amide functional group ( ellis 2002 ). Chem 216 s11 notes - dr masato koreeda date: may 3, 2011 topic: __experiment 1____ page 2 of 2 additional comments on the reaction mechanism: 1 aniline is a strong nucleophile (much stronger than water. Organic synthesis is a very common process and much like the synthesis done in this experiment, another common one is the synthesis of aspirin this synthesis is extremely similar to the procedure done in this experiment in that instead of p-aminophenol, salicylic acid is combined with acetic anhydride to produce aspirin and acetic acid.
Anal 2b1 synthesis of acetaminophen experimental techniques required recrystallisation (t 2), filtration (t 3), melting point determination (t 4), yield calculation (t 14. Chem m52lc experiment 1 page 5 caution wear gloves and safety glasses and conduct all aspects of this synthesis in a hood the organic solvents used in this laboratory experiment (acetone, diethyl ether are volatile. Figure 1: acetaminophen structure the acetaminophen was the end product of this experiment, it was formed by recrystallization the recrystallization stage occurred when drops of hot water/methanol solvent was added to the crude product to completely dissolve the crystals. The crude acetaminophen was then recrystallized in a solvent of water and methanol over heat resulting in 0082 grams (3961% yield) of pure acetaminophen melting points of both crude and pure acetaminophen were taken, and found to be 1659 - 1709°c and 1682 - 1715°c, respectively.